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GeneMANIA: Fast Gene Function Predictions

Tutorial and training materials by OpenHelix

Learn to use GeneMANIA, a free public resource that offers a simple, intuitive web interface that shows the relationships between genes in a list and analyzes and extends the list to include other related genes. Download the example data file used in the tutorial file by clicking here.
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You'll learn:

  • how to do basic searches and understand result displays
  • the importance of selecting the data types and datasets included in analyses
  • how changing network weighting can improve your output predictions
  • to format your own data and upload it for inclusion in GeneMANIA analyses
  • the many advantages of using GeneMANIA


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Recent BioMed Central research articles citing this resource

Azuaje J Francisco et al., Predictive integration of gene functional similarity and co-expression defines treatment response of endothelial progenitor cells. BMC Systems Biology (2011) doi:10.1186/1752-0509-5-46

Rouchka C Eric et al., Proceedings of the Tenth Annual UT-ORNL-KBRIN Bioinformatics Summit 2011 UT-ORNL-KBRIN Bioinformatics Summit 2011 10 th Annual UT-ORNL-KBRIN Bioinformatics Summit 2011. BMC Bioinformatics (2011) doi:10.1186/1471-2105-12-S7-A1

Schietgat Leander et al., Predicting gene function using hierarchical multi-label decision tree ensembles. BMC Bioinformatics (2010) doi:10.1186/1471-2105-11-2

Jain Shobhit et al., An improved method for scoring protein-protein interactions using semantic similarity within the gene ontology. BMC Bioinformatics (2010) doi:10.1186/1471-2105-11-562

Gillis Jesse et al., A methodology for the analysis of differential coexpression across the human lifespan. BMC Bioinformatics (2009) doi:10.1186/1471-2105-10-306

More about the resource:

GeneMANIA was developed, and is maintained by the GeneMANIA team based in the Donnelly Centre for Cellular and Biomedical Research at the University of Toronto.


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The materials and slides offered can not be resold or used for profit purposes. Reproduction, distribution and/or use is strictly limited to instructional purposes only and can not be used for for monetary gain or wide distribution.
Copyright 2009, OpenHelix, LLC.

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