Database of Genomic Variants, DGV, catalogs and displays structural variation in the human genome
Tutorial and training materials by OpenHelix
|Learn to use The Database of Genomic Variants, or DGV , a curated catalog of structural variation within the human genome. All variation data is from normal non-diseased controls, yet the ramifications of the data go well beyond their role in normal phenotypic variability. Many highly variable regions are extremely important in disease and this field is only in its infancy currently. Copy-number variations, or CNVs, are under active pursuit. DGV™s user-friendly format allows you to easily browse variation data in tabular or graphic format organized by chromosome location. Users can search by keywords, chromosome location, genes, sequence and more. Each variation entry has extensive details including where the original data was extracted from, links to many other resources, methodology, study details and the ability to view and manipulate your data using the DGV™s GBrowse-based genome browser or UCSC and Ensembl's genome browsers.|
Note: A new version of DGV has just launched. We will update this material soon to correspond with the new interface. Many of the concepts will remain the same, and a track of the data from the prior version will be available. For more details, see: Official Launch of the new Database of Genomic Variants (DGV) .
- to browse and search through DGVâ€™s structural variant data
- how to find, understand and link to more genomic variation details
- to navigate and customize your data using the genome browser
- how to perform a BLAT sequence search
View additional tutorials for resources in
Recent BioMed Central research articles citing this resource
Sandbacka Maria et al., TBX6, LHX1 and copy number variations in the complex genetics of MĂĽllerian aplasia. Orphanet Journal of Rare Diseases (2013) doi:10.1186/1750-1172-8-125
Sebastiana MĂłnica et al., A possible approach for gel-based proteomic studies in recalcitrant woody plants Biomedical and Life Sciences. SpringerPlus (2013) doi:10.1186/2193-1801-2-210
BoonPeng Hoh et al., The utility of copy number variation (CNV) in studies of hypertension-related left ventricular hypertrophy (LVH): rationale, potential and challenges. Molecular Cytogenetics (2013) doi:10.1186/1755-8166-6-8
Kripke F Daniel et al., FMR1 , circadian genes and depression: suggestive associations or false discovery?. Journal of Circadian Rhythms (2013) doi:10.1186/1740-3391-11-3
Tryggestad B Jeanie et al., Hypogonadotropic hypogonadism presenting with arhinia: a case report. Journal of Medical Case Reports (2013) doi:10.1186/1752-1947-7-52
More about the resource:
DGV is hosted by the Centre for Applied Genomics located at the Hospital for Sick Children in Toronto, Canada. The majority of the structural variant data you find in DGV are Copy Number Variants, or CNVs, due to their prevalence in the human genome, but you also will see inversion and InDel data whenever it is available. The data is structured and clearly organized so that you can navigate to more details using both internal and external links with ease. DGV offers many useful resources, such as a newsletter and mailing list, which can also help to keep you abreast of all the latest DGV developments.
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