Database of Genomic Variants, DGV, catalogs and displays structural variation in the human genome
Tutorial and training materials by OpenHelix
|Learn to use The Database of Genomic Variants, or DGV , a curated catalog of structural variation within the human genome. All variation data is from normal non-diseased controls, yet the ramifications of the data go well beyond their role in normal phenotypic variability. Many highly variable regions are extremely important in disease and this field is only in its infancy currently. Copy-number variations, or CNVs, are under active pursuit. DGV’s user-friendly format allows you to easily browse variation data in tabular or graphic format organized by chromosome location. Users can search by keywords, chromosome location, genes, sequence and more. Each variation entry has extensive details including where the original data was extracted from, links to many other resources, methodology, study details and the ability to view and manipulate your data using the DGV’s GBrowse-based genome browser or UCSC and Ensembl’s genome browsers.|
- to browse and search through DGV’s structural variant data
- how to find, understand and link to more genomic variation details
- to navigate and customize your data using the genome browser
- how to perform a BLAT sequence search
View additional tutorials for resources in
Recent BioMed Central research articles citing this resource
Qi Qingwei et al., A rare de novo duplication of chromosome 21q22.12 → q22.3 with other concomitant deletion and duplication of small fragments in 21q associated with Down syndrome: Prenatal diagnosis, molecular cytogenetic characterization. Molecular Cytogenetics (2013) doi:10.1186/1755-8166-6-11
Ewing D Adam et al., Retrotransposition of gene transcripts leads to structural variation in mammalian genomes. Genome Biology (2013) doi:10.1186/gb-2013-14-3-r22
Wittler Roland et al., Unraveling overlapping deletions by agglomerative clustering Selected articles from the Eleventh Asia Pacific Bioinformatics Conference (APBC 2013): Genomics The Eleventh Asia Pacific Bioinformatics Conference (APBC 2013). BMC Genomics (2013) doi:10.1186/1471-2164-14-S1-S12
Di Benedetto Daniela et al., 6p22.3 deletion: report of a patient with autism, severe intellectual disability and electroencephalographic anomalies. Molecular Cytogenetics (2013) doi:10.1186/1755-8166-6-4
Barøy Tuva et al., Haploinsufficiency of two histone modifier genes on 6p22.3, ATXN1 and JARID2 , is associated with intellectual disability. Orphanet Journal of Rare Diseases (2013) doi:10.1186/1750-1172-8-3
More about the resource:
DGV is hosted by the Centre for Applied Genomics located at the Hospital for Sick Children in Toronto, Canada. The majority of the structural variant data you find in DGV are Copy Number Variants, or CNVs, due to their prevalence in the human genome, but you also will see inversion and InDel data whenever it is available. The data is structured and clearly organized so that you can navigate to more details using both internal and external links with ease. DGV offers many useful resources, such as a newsletter and mailing list, which can also help to keep you abreast of all the latest DGV developments.
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