Learn to use the UniProt Knowledgebase, which has detailed curated information about known proteins, with predictions and computational assignments for both characterized and uncharacterized proteins. The UniRef layer provides clustered handy links to related proteins. UniParc archive records collect non-redundant but complete collections of protein sequence data. This tutorial will explore each type of record--UniProt, UniRef, and UniParc, and examine available search strategies. This resource is a foundational tool for proteomics research.
You will learn:
This tutorial is a part of the tutorial group Advanced Analysis and Queries. You might find the other tutorials in the group interesting:
BioMart: Management and querying of many types of biological data
DBTSS: Database of Transcriptional Start Sites
ENCODE Data at UCSC: ENCODE Data at UCSC
Galaxy: Analysis tools for researchers
This tutorial is a part of the tutorial group Protein-centric and protein structure resources. You might find the other tutorials in the group interesting:
Pfam: Protein Domain families
RCSB PDB: RCSB Protein Data Bank
MMDB: Molecular Modeling Database at NCBI
Entrez Protein: NCBI's Entrez Protein for amino acid-centric information
Structural Biology Knowledgebase: The Protein Structure Initiative Structural Biology Knowledgebase
Algorithms and Analysis : This category contains various tools that may help perform analysis of different genomics data types. This may include sequence alignment, large-scale or complex queries, motif finding, or comparative assessments.
Proteins : Tools that are primarily used in the storage, retrieval, or exploration of amino acid based data. Some tools may also involve nucleotide sequence information.
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Recent BioMed Central research articles citing this resource
Huang Kai-Yao et al., A new scheme to discover functional associations and regulatory networks of E3 ubiquitin ligases. BMC Systems Biology (2016) doi:10.1186/s12918-015-0244-1
Buffon P. Marjoriê et al., rs1888747 polymorphism in the FRMD3 gene, gene and protein expression: role in diabetic kidney disease. Diabetology Metabolic Syndrome (2016) doi:10.1186/s13098-015-0121-5
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Lozano-Amado Daniela et al., Identification of repressive and active epigenetic marks and nuclear bodies in Entamoeba histolytica. Parasites Vectors (2016) doi:10.1186/s13071-016-1298-7