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UniProt, Universal Protein Resource

Tutorial and training materials by OpenHelix

Learn to use the UniProt Knowledgebase, which has detailed curated information about known proteins, with predictions and computational assignments for both characterized and uncharacterized proteins. The UniRef layer provides clustered handy links to related proteins. UniParc archive records collect non-redundant but complete collections of protein sequence data. This tutorial will explore each type of record--UniProt, UniRef, and UniParc, and examine available search strategies. This resource is a foundational tool for proteomics research.
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You'll learn:

  • to perform text searches for relevant protein information
  • to search with sequences as a starting point
  • to understand the different types of UniProt records
  • to create multi-sequence alignments from protein records using Clustal


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Recent BioMed Central research articles citing this resource

Potier Delphine et al., Identification of cis-regulatory modules encoding temporal dynamics during development Multicellular invertebrate genomics. BMC Genomics (2014) doi:10.1186/1471-2164-15-534

Iwata Keiko et al., N -ethylmaleimide-sensitive factor interacts with the serotonin transporter and modulates its trafficking: implications for pathophysiology in autism. Molecular Autism (2014) doi:10.1186/2040-2392-5-33

Whelehan J Cormac et al., Characterisation and expression profile of the bovine cathelicidin gene repertoire in mammary tissue Non-human and non-rodent vertebrate genomics. BMC Genomics (2014) doi:10.1186/1471-2164-15-128

Folkman Lukas et al., Towards sequence-based prediction of mutation-induced stability changes in unseen non-homologous proteins Selected articles from the Twelfth Asia Pacific Bioinformatics Conference (APBC 2014): Genomics The Twelfth Asia Pacific Bioinformatics Conference (APBC 2014). BMC Genomics (2014) doi:10.1186/1471-2164-15-S1-S4

Tilli M Tatiana et al., Changes in the transcriptional profile in response to overexpression of the osteopontin-c splice isoform in ovarian (OvCar-3) and prostate (PC-3) cancer cell lines Cell and molecular biology. BMC Cancer (2014) doi:10.1186/1471-2407-14-433

More about the resource:

The UniProt Resource which is a centralized database for protein sequences and data, comes from the UniProt Consortium, a team consisting of members of the Swiss Bioinformatics Institute (SIB), the European Bioinformatics Institute (EBI), and the Protein Information Resource (PIR). These groups have come together to create a comprehensive and authoritative protein data resource for researchers.


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