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UniProt, Universal Protein Resource

Tutorial and training materials by OpenHelix

Learn to use the UniProt Knowledgebase, which has detailed curated information about known proteins, with predictions and computational assignments for both characterized and uncharacterized proteins. The UniRef layer provides clustered handy links to related proteins. UniParc archive records collect non-redundant but complete collections of protein sequence data. This tutorial will explore each type of record--UniProt, UniRef, and UniParc, and examine available search strategies. This resource is a foundational tool for proteomics research.
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You'll learn:

  • to perform text searches for relevant protein information
  • to search with sequences as a starting point
  • to understand the different types of UniProt records
  • to create multi-sequence alignments from protein records using Clustal


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Recent BioMed Central research articles citing this resource

Peng Jiajie et al., Towards integrative gene functional similarity measurement Selected articles from the Twelfth Asia Pacific Bioinformatics Conference (APBC 2014): Bioinformatics The Twelfth Asia Pacific Bioinformatics Conference (APBC 2014). BMC Bioinformatics (2014) doi:10.1186/1471-2105-15-S2-S5

Frantzi Maria et al., Clinical proteomic biomarkers: relevant issues on study design technical considerations in biomarker development Regular submissions. Clinical and Translational Medicine (2014) doi:10.1186/2001-1326-3-7

Näätsaari Laura et al., Peroxidase gene discovery from the horseradish transcriptome Transcriptomic methods. BMC Genomics (2014) doi:10.1186/1471-2164-15-227

Li Lin et al., Genome-wide discovery and characterization of maize long non-coding RNAs. Genome Biology (2014) doi:10.1186/gb-2014-15-2-r40

Van de Poel Bram et al., Tissue specific analysis reveals a differential organization and regulation of both ethylene biosynthesis and E8 during climacteric ripening of tomato Biochemistry and physiology. BMC Plant Biology (2014) doi:10.1186/1471-2229-14-11

More about the resource:

The UniProt Resource which is a centralized database for protein sequences and data, comes from the UniProt Consortium, a team consisting of members of the Swiss Bioinformatics Institute (SIB), the European Bioinformatics Institute (EBI), and the Protein Information Resource (PIR). These groups have come together to create a comprehensive and authoritative protein data resource for researchers.


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Copyright 2009, OpenHelix, LLC.

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