UniProt, Universal Protein Resource
Tutorial and training materials by OpenHelix
| Learn to use the UniProt Knowledgebase, which has detailed curated information about known proteins, with predictions and computational assignments for both characterized and uncharacterized proteins. The UniRef layer provides clustered handy links to related proteins. UniParc archive records collect non-redundant but complete collections of protein sequence data. This tutorial will explore each type of record--UniProt, UniRef, and UniParc, and examine available search strategies. This resource is a foundational tool for proteomics research. | Advertisement:
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You'll learn:
- to perform text searches for relevant protein information
- to search with sequences as a starting point
- to understand the different types of UniProt records
- to create multi-sequence alignments from protein records using Clustal
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Recent BioMed Central research articles citing this resourceBegara-Morales C Juan et al., Vinyl sulfone silica: application of an open preactivated support to the study of transnitrosylation of plant proteins by S-nitrosoglutathione Biochemistry and physiology. BMC Plant Biology (2013) doi:10.1186/1471-2229-13-61 Plak Katarzyna et al., GxcC connects Rap and Rac signaling during Dictyostelium development Cell signaling pathways and networks. BMC Cell Biology (2013) doi:10.1186/1471-2121-14-6 Dawson D Harry et al., Structural and functional annotation of the porcine immunome Non-human and non-rodent vertebrate genomics. BMC Genomics (2013) doi:10.1186/1471-2164-14-332 Calduch-Giner A Josep et al., Deep sequencing for de novo construction of a marine fish (Sparus aurata) transcriptome database with a large coverage of protein-coding transcripts Non-human and non-rodent vertebrate genomics. BMC Genomics (2013) doi:10.1186/1471-2164-14-178 Fujiwara Toyofumi et al., miRNA-target prediction based on transcriptional regulation Selected articles from ISCB-Asia 2012 ISCB-Asia 2012. BMC Genomics (2013) doi:10.1186/1471-2164-14-S2-S3 |
More about the resource:
The UniProt Resource which is a centralized database for protein sequences and data, comes from the UniProt Consortium, a team consisting of members of the Swiss Bioinformatics Institute (SIB), the European Bioinformatics Institute (EBI), and the Protein Information Resource (PIR). These groups have come together to create a comprehensive and authoritative protein data resource for researchers.
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