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UniProt, Universal Protein Resource

Tutorial and training materials by OpenHelix

Learn to use the UniProt Knowledgebase, which has detailed curated information about known proteins, with predictions and computational assignments for both characterized and uncharacterized proteins. The UniRef layer provides clustered handy links to related proteins. UniParc archive records collect non-redundant but complete collections of protein sequence data. This tutorial will explore each type of record--UniProt, UniRef, and UniParc, and examine available search strategies. This resource is a foundational tool for proteomics research.
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You'll learn:

  • to perform text searches for relevant protein information
  • to search with sequences as a starting point
  • to understand the different types of UniProt records
  • to create multi-sequence alignments from protein records using Clustal


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Recent BioMed Central research articles citing this resource

Can Tugba et al., Proteomic analysis of laser capture microscopy purified myotendinous junction regions from muscle sections. Proteome Science (2014) doi:10.1186/1477-5956-12-25

Meinhardt W Lyndel et al., Genome and secretome analysis of the hemibiotrophic fungal pathogen, Moniliophthora roreri , which causes frosty pod rot disease of cacao: mechanisms of the biotrophic and necrotrophic phases Eukaryote microbial genomics. BMC Genomics (2014) doi:10.1186/1471-2164-15-164

Abeyruwan Saminda et al., Evolving BioAssay Ontology (BAO): modularization, integration and applications Proceedings of the Bio-Ontologies Special Interest Group 2013 Bio-Ontologies Special Interest Group 2013. Journal of Biomedical Semantics (2014) doi:10.1186/2041-1480-5-S1-S5

Panjkovich Alejandro et al., antibacTR: dynamic antibacterial-drug-target ranking integrating comparative genomics, structural analysis and experimental annotation Prokaryote microbial genomics. BMC Genomics (2014) doi:10.1186/1471-2164-15-36

Diego-García Elia et al., The Mediterranean scorpion Mesobuthus gibbosus (Scorpiones, Buthidae): transcriptome analysis and organization of the genome encoding chlorotoxin-like peptides Non-human and non-rodent vertebrate genomics. BMC Genomics (2014) doi:10.1186/1471-2164-15-295

More about the resource:

The UniProt Resource which is a centralized database for protein sequences and data, comes from the UniProt Consortium, a team consisting of members of the Swiss Bioinformatics Institute (SIB), the European Bioinformatics Institute (EBI), and the Protein Information Resource (PIR). These groups have come together to create a comprehensive and authoritative protein data resource for researchers.


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