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UniProt, Universal Protein Resource

Tutorial and training materials by OpenHelix

Learn to use the UniProt Knowledgebase, which has detailed curated information about known proteins, with predictions and computational assignments for both characterized and uncharacterized proteins. The UniRef layer provides clustered handy links to related proteins. UniParc archive records collect non-redundant but complete collections of protein sequence data. This tutorial will explore each type of record--UniProt, UniRef, and UniParc, and examine available search strategies. This resource is a foundational tool for proteomics research.
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You'll learn:

  • to perform text searches for relevant protein information
  • to search with sequences as a starting point
  • to understand the different types of UniProt records
  • to create multi-sequence alignments from protein records using Clustal


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Recent BioMed Central research articles citing this resource

Sigdel K Tara et al., Optimization for peptide sample preparation for urine peptidomics. Clinical Proteomics (2014) doi:10.1186/1559-0275-11-7

Ehx Grégory et al., Liver proteomic response to hypertriglyceridemia in human-apolipoprotein C-III transgenic mice at cellular and mitochondrial compartment levels. Lipids in Health and Disease (2014) doi:10.1186/1476-511X-13-116

McCarthy W Thomas et al., Phylogenetic analysis of pectin-related gene families in Physcomitrella patens and nine other plant species yields evolutionary insights into cell walls Genomics and evolution. BMC Plant Biology (2014) doi:10.1186/1471-2229-14-79

Itzhak Daniel et al., Multiple autophosphorylations significantly enhance the endoribonuclease activity of human inositol requiring enzyme 1α Protein and enzyme biochemistry. BMC Biochemistry (2014) doi:10.1186/1471-2091-15-3

Kruger Stefan et al., Molecular characterization of exosome-like vesicles from breast cancer cells Systems biology, post-genomic analysis and emerging technologies. BMC Cancer (2014) doi:10.1186/1471-2407-14-44

More about the resource:

The UniProt Resource which is a centralized database for protein sequences and data, comes from the UniProt Consortium, a team consisting of members of the Swiss Bioinformatics Institute (SIB), the European Bioinformatics Institute (EBI), and the Protein Information Resource (PIR). These groups have come together to create a comprehensive and authoritative protein data resource for researchers.


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The materials and slides offered can not be resold or used for profit purposes. Reproduction, distribution and/or use is strictly limited to instructional purposes only and can not be used for for monetary gain or wide distribution.
Copyright 2009, OpenHelix, LLC.

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