UniProt, Universal Protein Resource
Tutorial and training materials by OpenHelix
|Learn to use the UniProt Knowledgebase, which has detailed curated information about known proteins, with predictions and computational assignments for both characterized and uncharacterized proteins. The UniRef layer provides clustered handy links to related proteins. UniParc archive records collect non-redundant but complete collections of protein sequence data. This tutorial will explore each type of record--UniProt, UniRef, and UniParc, and examine available search strategies. This resource is a foundational tool for proteomics research.|
- to perform text searches for relevant protein information
- to search with sequences as a starting point
- to understand the different types of UniProt records
- to create multi-sequence alignments from protein records using Clustal
Recent BioMed Central research articles citing this resource
Chen Linan et al., Global regulation of mRNA translation and stability in the early Drosophila embryo by the Smaug RNA-binding protein. Genome Biology (2014) doi:10.1186/gb-2014-15-1-r4
Simabuco Moreira Fernando et al., ADAM17 mediates OSCC development in an orthotopic murine model. Molecular Cancer (2014) doi:10.1186/1476-4598-13-24
Huang Tiao-Lai et al., 2D-DIGE proteome analysis on the platelet proteins of patients with major depression. Proteome Science (2014) doi:10.1186/1477-5956-12-1
Costa Odile et al., Proteomic profile of pre - B2 lymphoblasts from children with acute lymphoblastic leukemia (ALL) in relation with the translocation (12; 21). Clinical Proteomics (2014) doi:10.1186/1559-0275-11-31
Masseroli Marco et al., Explorative search of distributed bio-data to answer complex biomedical questions Integrated Bio-Search: Selected Works from the 12th International Workshop on Network Tools and Applications in Biology (NETTAB 2012) Integrated Bio-Search: 12th International Workshop on Network Tools and Applications in Biology (NETTAB 2012). BMC Bioinformatics (2014) doi:10.1186/1471-2105-15-S1-S3
More about the resource:
The UniProt Resource which is a centralized database for protein sequences and data, comes from the UniProt Consortium, a team consisting of members of the Swiss Bioinformatics Institute (SIB), the European Bioinformatics Institute (EBI), and the Protein Information Resource (PIR). These groups have come together to create a comprehensive and authoritative protein data resource for researchers.
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