HapMap, a database and analysis resource of human variation
Tutorial and training materials by OpenHelix
|Learn to use HapMap, a database and analysis resource of human variation. The HapMap project identified and cataloged genetic variation in human beings in four populations with African, Asian, and European ancestry. This freely available database and variation browser contains much of the known variation of the Human genome and researchers can use the data to determine variations that affect health, disease, and individual responses to medications and environmental factors. Learn to use the genome browser associated with this project to view HapMap data, retrieve genotypes and find frequencies for genomic regions.|
- to find SNPs of interest with advanced searching
- how to determine linkage disequilibrium between SNPs
- how to find candidate tag SNPs to better design genotyping assays
- where to download and how to use the HaploView software for deeper SNP analysis
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Recent BioMed Central research articles citing this resource
Vasseur Francis et al., The CARD8 p.C10X mutation associates with a low anti-glycans antibody response in patients with Crohn’s disease Genetic epidemiology and genetic associations. BMC Medical Genetics (2013) doi:10.1186/1471-2350-14-35
Amarasinghe C Kaushalya et al., CoNVEX: copy number variation estimation in exome sequencing data using HMM Selected articles from the Eleventh Asia Pacific Bioinformatics Conference (APBC 2013): Bioinformatics The Eleventh Asia Pacific Bioinformatics Conference (APBC 2013). BMC Bioinformatics (2013) doi:10.1186/1471-2105-14-S2-S2
Soto-Ramírez Nelís et al., The interaction of genetic variants and DNA methylation of the interleukin-4 receptor gene increase the risk of asthma at age 18 years. Clinical Epigenetics (2013) doi:10.1186/1868-7083-5-1
Vardarajan Badri et al., Role of p73 in Alzheimer disease: lack of association in mouse models or in human cohorts. Molecular Neurodegeneration (2013) doi:10.1186/1750-1326-8-10
He Yongqun et al., Computational vaccinology and the ICoVax 2012 workshop Selected Articles on Computational Vaccinology The second ISV Pre-conference Computational Vaccinology Workshop (ICoVax 2012). BMC Bioinformatics (2013) doi:10.1186/1471-2105-14-S4-I1
More about the resource:
The International HapMap Project is a collaborative international effort of over 24 groups in six countries to identify and catalog human variation. The project has cataloged most of the probably 10 million SNPs estimated to occur in the Human Genome. The HapMap website includes a browser to view the SNP, haplotype, linkage disequilibrium and tag SNP data, an advanced search tool and software for deeper analysis. All data and tools are free and in the public domain.
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