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HapMap, a database and analysis resource of human variation

Tutorial and training materials by OpenHelix

Learn to use HapMap, a database and analysis resource of human variation. The HapMap project identified and cataloged genetic variation in human beings in four populations with African, Asian, and European ancestry. This freely available database and variation browser contains much of the known variation of the Human genome and researchers can use the data to determine variations that affect health, disease, and individual responses to medications and environmental factors. Learn to use the genome browser associated with this project to view HapMap data, retrieve genotypes and find frequencies for genomic regions.
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You'll learn:

  • to find SNPs of interest with advanced searching
  • how to determine linkage disequilibrium between SNPs
  • how to find candidate tag SNPs to better design genotyping assays
  • where to download and how to use the HaploView software for deeper SNP analysis


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Recent BioMed Central research articles citing this resource

Chung Sun-Ku et al., Genetic loci associated with changes in lipid levels leading to constitution-based discrepancy in Koreans Basic research. BMC Complementary and Alternative Medicine (2014) doi:10.1186/1472-6882-14-230

Koestler C Devin et al., Integrative genomic analysis identifies epigenetic marks that mediate genetic risk for epithelial ovarian cancer Genomic epidemiology. BMC Medical Genomics (2014) doi:10.1186/1755-8794-7-8

Gruel Nadège et al., Polarity gene alterations in pure invasive micropapillary carcinomas of the breast. Breast Cancer Research (2014) doi:10.1186/bcr3653

Smith N Erin et al., Genetic ancestry of participants in the National Children’s Study. Genome Biology (2014) doi:10.1186/gb-2014-15-2-r22

LaCroix Bonnie et al., Integrative analyses of genetic variation, epigenetic regulation, and the transcriptome to elucidate the biology of platinum sensitivity Transcriptomic methods. BMC Genomics (2014) doi:10.1186/1471-2164-15-292

More about the resource:

The International HapMap Project is a collaborative international effort of over 24 groups in six countries to identify and catalog human variation. The project has cataloged most of the probably 10 million SNPs estimated to occur in the Human Genome. The HapMap website includes a browser to view the SNP, haplotype, linkage disequilibrium and tag SNP data, an advanced search tool and software for deeper analysis. All data and tools are free and in the public domain.


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Copyright 2009, OpenHelix, LLC.

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