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HapMap, a database and analysis resource of human variation

Tutorial and training materials by OpenHelix

Learn to use HapMap, a database and analysis resource of human variation. The HapMap project identified and cataloged genetic variation in human beings in four populations with African, Asian, and European ancestry. This freely available database and variation browser contains much of the known variation of the Human genome and researchers can use the data to determine variations that affect health, disease, and individual responses to medications and environmental factors. Learn to use the genome browser associated with this project to view HapMap data, retrieve genotypes and find frequencies for genomic regions.
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You'll learn:

  • to find SNPs of interest with advanced searching
  • how to determine linkage disequilibrium between SNPs
  • how to find candidate tag SNPs to better design genotyping assays
  • where to download and how to use the HaploView software for deeper SNP analysis


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Recent BioMed Central research articles citing this resource

Talwar Puneet et al., Genomic convergence and network analysis approach to identify candidate genes in Alzheimer"s disease Human and rodent genomics. BMC Genomics (2014) doi:10.1186/1471-2164-15-199

Yang Hsin-Chou et al., Applying genome-wide gene-based expression quantitative trait locus mapping to study population ancestry and pharmacogenetics Human and rodent genomics. BMC Genomics (2014) doi:10.1186/1471-2164-15-319

Cha Seongwon et al., Effects of apolipoprotein A5 haplotypes on the ratio of triglyceride to high-density lipoprotein cholesterol and the risk for metabolic syndrome in Koreans. Lipids in Health and Disease (2014) doi:10.1186/1476-511X-13-45

Yang Binyao et al., A genome-wide association study identifies common variants influencing serum uric acid concentrations in a Chinese population Genomic epidemiology. BMC Medical Genomics (2014) doi:10.1186/1755-8794-7-10

Marques Z Francine et al., Measurement of absolute copy number variation reveals association with essential hypertension Functional and structural genomics. BMC Medical Genomics (2014) doi:10.1186/1755-8794-7-44

More about the resource:

The International HapMap Project is a collaborative international effort of over 24 groups in six countries to identify and catalog human variation. The project has cataloged most of the probably 10 million SNPs estimated to occur in the Human Genome. The HapMap website includes a browser to view the SNP, haplotype, linkage disequilibrium and tag SNP data, an advanced search tool and software for deeper analysis. All data and tools are free and in the public domain.


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