Learn to use the Entrez Gene resource, a gene-centered collection of information from databases maintained by the National Center for Biotechnology Information (NCBI) and from other sources. Genes with defined sequences, known map positions, and genes inferred from phenotypic information are included, and information is added to these records when it becomes available. Entrez Gene records are extensively annotated and linked to provide you with easy access to many types of related information, including literature, taxonomy, conserved domains, GEO Profiles, chemical compound and substance data and more.

You will learn:

  • basic and advanced searches, including complex Boolean strategies
  • to understand the detailed gene reports provided
  • how to navigate, understand and customize output displays
  • additional features, such as options for saving searches, setting filters, and more


This tutorial is a part of the tutorial group Alignment and comparison resources. You might find the other tutorials in the group interesting:

ClustalW2: Performs multiple sequence alignments

BLAST: Basic Local Alignment and Search Tool

FASTA: FASTA sequence algorithm

Primer3: Pick primers from a DNA sequence.

DCODE: DCODE.org Comparative Genomics Developments, a collection of powerful comparative genomics tools

VISTA: Tools for Comparative Genomics

RefSeq: Provides molecular sequence records to help locate gene and protein data.


Nucleotides : Tools that are primarily used in the storage, retrieval, or exploration of nucleotide-based data. Some tools may also involve protein sequence information.

NCBI : This category includes resources maintained at the National Center for Biotechnology Information (NCBI).


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Tip of the Week: LAMHDI for animal models: At the Experimental Biology conference last week, we were "booth neighbors" with a group providing a database that we hadn't heard of--LAMHDI. Of course, we love to explore new software that serves ne...

Tip of the Week: BioGPS for expression data and more: This week's tip introduces BioGPS, or Gene Portal System. We get a lot of questions about two things that BioGPS can help you to tackle: what do I do with a list of genes to find out what they are? An...

BioGene: iPhone app for NCBI searches from MSKCC team: I can't remember how I got on this email list--but I like it :)  Today I was notified that there was a handy iPhone app to quickly get gene info out of the NCBI resources.  I wish I had this last week ...

Gene Wiki?: PLoS Biology has an article out today entitled "A Gene Wiki for Community Annotation of Gene Function." The article describes the authors attempts to create a comprehensive gene wiki of gene functions...


Recent BioMed Central research articles citing this resource

Hristovski Dimitar et al., Biomedical question answering using semantic relations Knowledge-based analysis. BMC Bioinformatics (2015) doi:10.1186/s12859-014-0365-3

Gari Mamdooh et al., Incidence and potential causative factors associated with chronic benign neutropenia in the Kingdom of Saudi Arabia Selected article from the 2nd International Genomic Medicine Conference (IGMC 2013): Proceedings 2nd International Genomic Medicine Conference (IGMC 2013). BMC Proceedings (2015) doi:10.1186/1753-6561-9-S2-S1

Rutar Matt et al., Chemokine-mediated inflammation in the degenerating retina is coordinated by Müller cells, activated microglia, and retinal pigment epithelium. Journal of Neuroinflammation (2015) doi:10.1186/s12974-014-0224-1

Wille Michael et al., The proteome profiles of the olfactory bulb of juvenile, adult and aged rats - an ontogenetic study. Proteome Science (2015) doi:10.1186/s12953-014-0058-x

Zhu Jun et al., A systems genetics study of swine illustrates mechanisms underlying human phenotypic traits. BMC Genomics (2015) doi:10.1186/s12864-015-1240-y