Learn to use the Entrez Gene resource, a gene-centered collection of information from databases maintained by the National Center for Biotechnology Information (NCBI) and from other sources. Genes with defined sequences, known map positions, and genes inferred from phenotypic information are included, and information is added to these records when it becomes available. Entrez Gene records are extensively annotated and linked to provide you with easy access to many types of related information, including literature, taxonomy, conserved domains, GEO Profiles, chemical compound and substance data and more.

You will learn:

  • basic and advanced searches, including complex Boolean strategies
  • to understand the detailed gene reports provided
  • how to navigate, understand and customize output displays
  • additional features, such as options for saving searches, setting filters, and more


This tutorial is a part of the tutorial group Alignment and comparison resources. You might find the other tutorials in the group interesting:

ClustalW2: Performs multiple sequence alignments

BLAST: Basic Local Alignment and Search Tool

FASTA: FASTA sequence algorithm

Primer3: Pick primers from a DNA sequence.

DCODE: DCODE.org Comparative Genomics Developments, a collection of powerful comparative genomics tools

VISTA: Tools for Comparative Genomics

RefSeq: Provides molecular sequence records to help locate gene and protein data.


Nucleotides : Tools that are primarily used in the storage, retrieval, or exploration of nucleotide-based data. Some tools may also involve protein sequence information.

NCBI : This category includes resources maintained at the National Center for Biotechnology Information (NCBI).


Video Tip of the Week: PheGenI, Phenotype-Genotype Integrator: The hunt for variations in genes and genomes has been both fruitful and frustrating. We can see genome variations in a variety of ways, but we can't always connect them with a phenotype easily. And vic...

Tip of the Week: LAMHDI for animal models: At the Experimental Biology conference last week, we were "booth neighbors" with a group providing a database that we hadn't heard of--LAMHDI. Of course, we love to explore new software that serves ne...

Tip of the Week: BioGPS for expression data and more: This week's tip introduces BioGPS, or Gene Portal System. We get a lot of questions about two things that BioGPS can help you to tackle: what do I do with a list of genes to find out what they are? An...

BioGene: iPhone app for NCBI searches from MSKCC team: I can't remember how I got on this email list--but I like it :)  Today I was notified that there was a handy iPhone app to quickly get gene info out of the NCBI resources.  I wish I had this last week ...

Gene Wiki?: PLoS Biology has an article out today entitled "A Gene Wiki for Community Annotation of Gene Function." The article describes the authors attempts to create a comprehensive gene wiki of gene functions...


Recent BioMed Central research articles citing this resource

Hakenberg Jörg et al., Integrating 400 million variants from 80,000 human samples with extensive annotations: towards a knowledge base to analyze disease cohorts Sequence analysis (applications). BMC Bioinformatics (2016) doi:10.1186/s12859-015-0865-9

Yu Hasun et al., Prediction of drugs having opposite effects on disease genes in a directed network. BMC Systems Biology (2016) doi:10.1186/s12918-015-0243-2

Buffon P. Marjoriê et al., rs1888747 polymorphism in the FRMD3 gene, gene and protein expression: role in diabetic kidney disease. Diabetology Metabolic Syndrome (2016) doi:10.1186/s13098-015-0121-5

Bertoni Natália et al., Integrative meta-analysis identifies microRNA-regulated networks in infantile hemangioma Clinical-Molecular Genetics and Cytogenetics. BMC Medical Genetics (2016) doi:10.1186/s12881-015-0262-2

Chen Yuan et al., Informative gene selection and the direct classification of tumors based on relative simplicity Results and data. BMC Bioinformatics (2016) doi:10.1186/s12859-016-0893-0