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Basic Local Alignment and Search Tool

Tutorial and training materials by OpenHelix

Learn to use BLAST, (Basic Local Alignment and Search Tool), the sequence similarity searching tool from the National Center for Biotechnology Information (NCBI) at NIH. You can use BLAST to find sequences similar to your nucleotide or protein sequences. There are also a variety of specialized BLAST programs available, including Primer-BLAST, VecScreen, SNP BLAST options, multiple alignment tools, and more. You can easily compare 2 sequences to each other. These can provide invaluable information in your quest to infer functional and taxonomic relationships for known or unknown sequences, or to further design experiments.
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You'll learn:

  • how to do basic nucleotide and protein BLAST searches
  • how to interpret and save your BLAST results
  • how to manipulate your data for easy analysis and visualization
  • to customize and save your searches and results with My NCBI
  • to use some of the specialized BLAST tools for multiple alignments and SNP analysis


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Recent BioMed Central research articles citing this resource

Jin Wei et al., Discovery of a novel rumen methanogen in the anaerobic fungal culture and its distribution in the rumen as revealed by real-time PCR Ecological and evolutionary microbiology. BMC Microbiology (2014) doi:10.1186/1471-2180-14-104

Ripp Fabian et al., All-Food-Seq (AFS): a quantifiable screen for species in biological samples by deep DNA sequencing Comparative and evolutionary genomics. BMC Genomics (2014) doi:10.1186/1471-2164-15-639

Meiyalaghan Sathiyamoorthy et al., Structure and expression of GSL1 and GSL2 genes encoding gibberellin stimulated-like proteins in diploid and highly heterozygous tetraploid potato reveals their highly conserved and essential status Plant genomics. BMC Genomics (2014) doi:10.1186/1471-2164-15-2

Doddamani Dadakhalandar et al., CicArMiSatDB: the chickpea microsatellite database Sequence analysis (applications). BMC Bioinformatics (2014) doi:10.1186/1471-2105-15-212

Bradley S Barrie et al., Differential expression of microRNAs as predictors of glioblastoma phenotypes Results and data. BMC Bioinformatics (2014) doi:10.1186/1471-2105-15-21

More about the resource:

BLAST is a key resource developed and supported by the National Center for Biotechnology Information (NCBI). Sequence submissions from around the world help to populate NCBI's Genbank database, to which novel sequences can be compared using BLAST. BLAST results are linked to the vast NCBI Entrez network of databases allowing for a rich resource for discovery.


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The materials and slides offered can not be resold or used for profit purposes. Reproduction, distribution and/or use is strictly limited to instructional purposes only and can not be used for for monetary gain or wide distribution.
Copyright 2009, OpenHelix, LLC.

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