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Basic Local Alignment and Search Tool

Tutorial and training materials by OpenHelix

Learn to use BLAST, (Basic Local Alignment and Search Tool), the sequence similarity searching tool from the National Center for Biotechnology Information (NCBI) at NIH. You can use BLAST to find sequences similar to your nucleotide or protein sequences. There are also a variety of specialized BLAST programs available, including Primer-BLAST, VecScreen, SNP BLAST options, multiple alignment tools, and more. You can easily compare 2 sequences to each other. These can provide invaluable information in your quest to infer functional and taxonomic relationships for known or unknown sequences, or to further design experiments.
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You'll learn:

  • how to do basic nucleotide and protein BLAST searches
  • how to interpret and save your BLAST results
  • how to manipulate your data for easy analysis and visualization
  • to customize and save your searches and results with My NCBI
  • to use some of the specialized BLAST tools for multiple alignments and SNP analysis


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Recent BioMed Central research articles citing this resource

Shi Hao et al., Molecular analysis of hyperthermophilic endoglucanase Cel12B from Thermotoga maritima and the properties of its functional residues Computational analysis. BMC Structural Biology (2014) doi:10.1186/1472-6807-14-8

Ghaffarpour Massoud et al., The mitochondrial ATPase6 gene is more susceptible to mutation than the ATPase8 gene in breast cancer patients. Cancer Cell International (2014) doi:10.1186/1475-2867-14-21

Ma John Man Chun et al., Genomic structure of nucleotide diversity among Lyon rat models of metabolic syndrome Human and rodent genomics. BMC Genomics (2014) doi:10.1186/1471-2164-15-197

Hu Yong-hua et al., Edwardsiella tarda Hfq: impact on host infection and global protein expression. Veterinary Research (2014) doi:10.1186/1297-9716-45-23

Hatje Klas et al., Kassiopeia: a database and web application for the analysis of mutually exclusive exomes of eukaryotes Comparative and evolutionary genomics. BMC Genomics (2014) doi:10.1186/1471-2164-15-115

More about the resource:

BLAST is a key resource developed and supported by the National Center for Biotechnology Information (NCBI). Sequence submissions from around the world help to populate NCBI's Genbank database, to which novel sequences can be compared using BLAST. BLAST results are linked to the vast NCBI Entrez network of databases allowing for a rich resource for discovery.


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The materials and slides offered can not be resold or used for profit purposes. Reproduction, distribution and/or use is strictly limited to instructional purposes only and can not be used for for monetary gain or wide distribution.
Copyright 2009, OpenHelix, LLC.

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