Performs multiple sequence alignments
Tutorial and training materials by OpenHelix
|Learn to use the ClustalW2 resource at the EBI Toolbox site for performing multiple sequence alignments, or MSA. MSA allow us to analyze the evolutionary relationship between species on a molecular sequence level. As well, multiple sequence alignments can help us to identify functionally important positions in a sequence family by simply looking at the conservation of positions or motifs within the sequence data.|
Download the example data file by clicking here.
- some background and theory for multiple sequence alignments
- how to conduct sequence alignments using
- to understand and adjust the results of ClustalW2 alignments
Recent BioMed Central research articles citing this resource
Dupont-Rouzeyrol Myrielle et al., Epidemiological and molecular features of dengue virus type-1 in New Caledonia, South Pacific, 2001–2013 Positive-strand RNA viruses. Virology Journal (2014) doi:10.1186/1743-422X-11-61
Janssen Ralf et al., Onychophoran Hox genes and the evolution of arthropod Hox gene expression. Frontiers in Zoology (2014) doi:10.1186/1742-9994-11-22
Yang Shanshan et al., CONSTANS is a photoperiod regulated activator of flowering in sorghum Genetics and crop biotechnology. BMC Plant Biology (2014) doi:10.1186/1471-2229-14-148
Wagner Glauber et al., STINGRAY: system for integrated genomic resources and analysis. BMC Research Notes (2014) doi:10.1186/1756-0500-7-132
Wang Jing et al., Evidence for the evolutionary origin of goldfish derived from the distant crossing of red crucian carp × common carp Animal population genetics. BMC Genetics (2014) doi:10.1186/1471-2156-15-33
More about the resource:
ClustalW2 web-based interface featured in this tutorial is provided by the European Bioinformatics Institute (EBI). The Clustal program was originally published by Thompson et al from Toby Gibsons group in 1994, and was later updated by Larkin et al. ClustalW can be downloaded as source code or as binaries for various operating systems at www.clustal.org, provided by the Conway Institute at the University College of Dublin.
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