Performs multiple sequence alignments
Tutorial and training materials by OpenHelix
|Learn to use the ClustalW2 resource at the EBI Toolbox site for performing multiple sequence alignments, or MSA. MSA allow us to analyze the evolutionary relationship between species on a molecular sequence level. As well, multiple sequence alignments can help us to identify functionally important positions in a sequence family by simply looking at the conservation of positions or motifs within the sequence data.|
Download the example data file by clicking here.
- some background and theory for multiple sequence alignments
- how to conduct sequence alignments using
- to understand and adjust the results of ClustalW2 alignments
Recent BioMed Central research articles citing this resource
Madslien H Elisabeth et al., L-alanine-induced germination in Bacillus licheniformis -the impact of native gerA sequences Microbial biochemistry, physiology and metabolism. BMC Microbiology (2014) doi:10.1186/1471-2180-14-101
Newell A Mark et al., Genetic and biochemical differences in populations bred for extremes in maize grain methionine concentration Genetics and crop biotechnology. BMC Plant Biology (2014) doi:10.1186/1471-2229-14-49
Tanifuji Goro et al., Nucleomorph and plastid genome sequences of the chlorarachniophyte Lotharella oceanica : convergent reductive evolution and frequent recombination in nucleomorph-bearing algae Comparative and evolutionary genomics. BMC Genomics (2014) doi:10.1186/1471-2164-15-374
Lin Chao-Nan et al., Genetic characterization of type 2a canine parvoviruses from Taiwan reveals the emergence of an Ile324 mutation in VP2 Veterinary DNA viruses. Virology Journal (2014) doi:10.1186/1743-422X-11-39
Buza Teresia et al., Computational prediction of disease microRNAs in domestic animals Bioinformatics. BMC Research Notes (2014) doi:10.1186/1756-0500-7-403
More about the resource:
ClustalW2 web-based interface featured in this tutorial is provided by the European Bioinformatics Institute (EBI). The Clustal program was originally published by Thompson et al from Toby Gibsons group in 1994, and was later updated by Larkin et al. ClustalW can be downloaded as source code or as binaries for various operating systems at www.clustal.org, provided by the Conway Institute at the University College of Dublin.
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