Performs multiple sequence alignments
Tutorial and training materials by OpenHelix
|Learn to use the ClustalW2 resource at the EBI Toolbox site for performing multiple sequence alignments, or MSA. MSA allow us to analyze the evolutionary relationship between species on a molecular sequence level. As well, multiple sequence alignments can help us to identify functionally important positions in a sequence family by simply looking at the conservation of positions or motifs within the sequence data.|
Download the example data file by clicking here.
- some background and theory for multiple sequence alignments
- how to conduct sequence alignments using
- to understand and adjust the results of ClustalW2 alignments
Recent BioMed Central research articles citing this resource
Kotlan Beatrix et al., Revealing cancer initiating cells in metastatic melanomas by harnessing the host′s anti tumor humoral immune mechanisms Melanoma Bridge 2013: Poster and Oral Presentations Melanoma Bridge meeting 2013. Journal of Translational Medicine (2014) doi:10.1186/1479-5876-12-S1-O1
Deubelbeiss Martina et al., Characterization of small ruminant lentivirus A4 subtype isolates and assessment of their pathogenic potential in naturally infected goats Retroviruses. Virology Journal (2014) doi:10.1186/1743-422X-11-65
Whelehan J Cormac et al., Characterisation and expression profile of the bovine cathelicidin gene repertoire in mammary tissue Non-human and non-rodent vertebrate genomics. BMC Genomics (2014) doi:10.1186/1471-2164-15-128
Vasilakis Nikos et al., Mesoniviruses are mosquito-specific viruses with extensive geographic distribution and host range Emerging viruses. Virology Journal (2014) doi:10.1186/1743-422X-11-97
Bao Hong-Xia et al., Differential efficiency in exogenous DNA acquisition among closely related Salmonella strains: implications in bacterial speciation Ecological and evolutionary microbiology. BMC Microbiology (2014) doi:10.1186/1471-2180-14-157
More about the resource:
ClustalW2 web-based interface featured in this tutorial is provided by the European Bioinformatics Institute (EBI). The Clustal program was originally published by Thompson et al from Toby Gibsons group in 1994, and was later updated by Larkin et al. ClustalW can be downloaded as source code or as binaries for various operating systems at www.clustal.org, provided by the Conway Institute at the University College of Dublin.
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