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Performs multiple sequence alignments

Tutorial and training materials by OpenHelix

Learn to use the ClustalW2 resource at the EBI Toolbox site for performing multiple sequence alignments, or MSA. MSA allow us to analyze the evolutionary relationship between species on a molecular sequence level. As well, multiple sequence alignments can help us to identify functionally important positions in a sequence family by simply looking at the conservation of positions or motifs within the sequence data.
Download the example data file by clicking here.
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You'll learn:

  • some background and theory for multiple sequence alignments
  • how to conduct sequence alignments using
  • to understand and adjust the results of ClustalW2 alignments


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Recent BioMed Central research articles citing this resource

Bottacini Francesca et al., Comparative genomics of the Bifidobacterium breve taxon Comparative and evolutionary genomics. BMC Genomics (2014) doi:10.1186/1471-2164-15-170

Serrat Xavier et al., EMS mutagenesis in mature seed-derived rice calli as a new method for rapidly obtaining TILLING mutant populations. Plant Methods (2014) doi:10.1186/1746-4811-10-5

Liu Dandan et al., Cloning and characterization of an Eimeria necatrix gene encoding a gametocyte protein and associated with oocyst wall formation. Parasites Vectors (2014) doi:10.1186/1756-3305-7-27

Floch Pauline et al., Role of Campylobacter jejuni gamma-glutamyl transpeptidase on epithelial cell apoptosis and lymphocyte proliferation. Gut Pathogens (2014) doi:10.1186/1757-4749-6-20

Zolfaghari Emameh Reza et al., Bioinformatic analysis of beta carbonic anhydrase sequences from protozoans and metazoans. Parasites Vectors (2014) doi:10.1186/1756-3305-7-38

More about the resource:

ClustalW2 web-based interface featured in this tutorial is provided by the European Bioinformatics Institute (EBI). The Clustal program was originally published by Thompson et al from Toby Gibson’s group in 1994, and was later updated by Larkin et al. ClustalW can be downloaded as source code or as binaries for various operating systems at www.clustal.org, provided by the Conway Institute at the University College of Dublin.


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