Performs multiple sequence alignments
Tutorial and training materials by OpenHelix
|Learn to use the ClustalW2 resource at the EBI Toolbox site for performing multiple sequence alignments, or MSA. MSA allow us to analyze the evolutionary relationship between species on a molecular sequence level. As well, multiple sequence alignments can help us to identify functionally important positions in a sequence family by simply looking at the conservation of positions or motifs within the sequence data.|
Download the example data file by clicking here.
- some background and theory for multiple sequence alignments
- how to conduct sequence alignments using
- to understand and adjust the results of ClustalW2 alignments
Recent BioMed Central research articles citing this resource
Riveron M Jacob et al., A single mutation in the GSTe2 gene allows tracking of metabolically based insecticide resistance in a major malaria vector. Genome Biology (2014) doi:10.1186/gb-2014-15-2-r27
Huh Un Sung et al., APUM5, encoding a Pumilio RNA binding protein, negatively regulates abiotic stress responsive gene expression Plant-abiotic interactions. BMC Plant Biology (2014) doi:10.1186/1471-2229-14-75
Liu Nan et al., An atypical winter outbreak of hand, foot, and mouth disease associated with human enterovirus 71, 2010 Viral diseases. BMC Infectious Diseases (2014) doi:10.1186/1471-2334-14-123
Micallef L Melinda et al., Comparative analysis of hapalindole, ambiguine and welwitindolinone gene clusters and reconstitution of indole-isonitrile biosynthesis from cyanobacteria. BMC Microbiology (2014) doi:10.1186/s12866-014-0213-7
Sierocka Izabela et al., Female-specific gene expression in dioecious liverwort Pellia endiviifolia is developmentally regulated and connected to archegonia production Reproductive biology. BMC Plant Biology (2014) doi:10.1186/1471-2229-14-168
More about the resource:
ClustalW2 web-based interface featured in this tutorial is provided by the European Bioinformatics Institute (EBI). The Clustal program was originally published by Thompson et al from Toby Gibsons group in 1994, and was later updated by Larkin et al. ClustalW can be downloaded as source code or as binaries for various operating systems at www.clustal.org, provided by the Conway Institute at the University College of Dublin.
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