Performs multiple sequence alignments
Tutorial and training materials by OpenHelix
| Learn to use the ClustalW2 resource at the EBI Toolbox site for performing multiple sequence alignments, or MSA. MSA allow us to analyze the evolutionary relationship between species on a molecular sequence level. As well, multiple sequence alignments can help us to identify functionally important positions in a sequence family by simply looking at the conservation of positions or motifs within the sequence data. Download the example data file by clicking here. | Advertisement:
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You'll learn:
- some background and theory for multiple sequence alignments
- how to conduct sequence alignments using
- to understand and adjust the results of ClustalW2 alignments
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| Recent BioMed Central research articles citing this resourceFerri Lorenzo et al., New clinical and molecular insights on Barth syndrome. Orphanet Journal of Rare Diseases (2013) doi:10.1186/1750-1172-8-27 Korrodi-Gregório Luis et al., Identification and characterization of two distinct PPP1R2 isoforms in human spermatozoa Directional sensing and cell motility. BMC Cell Biology (2013) doi:10.1186/1471-2121-14-15 Xia Jun Hong et al., Whole genome scanning and association mapping identified a significant association between growth and a SNP in the IFABP-a gene of the Asian seabass Non-human and non-rodent vertebrate genomics. BMC Genomics (2013) doi:10.1186/1471-2164-14-295 Kristmundsson Árni et al., Sphaeromyxids form part of a diverse group of myxosporeans infecting the hepatic biliary systems of a wide range of host organisms. Parasites Vectors (2013) doi:10.1186/1756-3305-6-51 Shishido Keiko Tânia et al., Convergent evolution of [ D -Leucine 1 ] microcystin-LR in taxonomically disparate cyanobacteria Genome evolution and evolutionary systems biology. BMC Evolutionary Biology (2013) doi:10.1186/1471-2148-13-86 |
More about the resource:
ClustalW2 web-based interface featured in this tutorial is provided by the European Bioinformatics Institute (EBI). The Clustal program was originally published by Thompson et al from Toby Gibson’s group in 1994, and was later updated by Larkin et al. ClustalW can be downloaded as source code or as binaries for various operating systems at www.clustal.org, provided by the Conway Institute at the University College of Dublin.
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