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DCODE.org Comparative Genomics Developments, a collection of powerful comparative genomics tools

Tutorial and training materials by OpenHelix

Learn to use the tools at DCODE.org, which are a collection of powerful comparative genomics resources. DCODE tools enable the user to browse several vertebrate genomes and compare them to identify ECRs (or evolutionary conserved regions). These regions, conserved through time often perform important regulatory functions. DCODE tools not only enable the user to identify ECRs but also to perform pairwise and multiple sequence alignments to create conservation profiles and phylogenetic tress. DCODE resources also have the capability to identify proximal and distant regulatory elements and conserved transcription factor binding sites. This tutorial will give you an introduction and overview of several of the tools available at DCODE.org and soon you will be searching your genomes and sequences of interest for regulatory elements and increasing your understanding of the mechanisms of gene regulation hidden there.
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You'll learn:

  • how to conduct whole genome alignments and identify ECRs
  • how to create interactive conservation profiles and phylogenetic tress
  • how to identify proximal and distant regulatory elements in desired sequences
  • identify conserved transcription factor binding sites


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More about the resource:

DCODE, which stands for Comparative Genomics Developments was established in 2003 as a part of NCBI. The main goal of DCODE is to provide scientists with centralized access to a variety of tools that allow for comparative sequence analysis therefore aiding in the understanding of the vast array of gene regulatory networks that exist throughout vertebrate genomes.


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