Database of Biological Systems
Tutorial and training materials by OpenHelix
|BioSystems is a new NCBI database of biological systems. It contains a tremendous variety of information regarding groups of molecules that interact in many types of biological systems. Biological systems, or BioSystems, are broadly defined to include not only the more traditional signaling pathways, but also diseases, and more. Many associated components are described, including genes, proteins, small molecules, biomarkers and drugs. You can use this database to find all the molecules in a specific pathway, to find pathways in which a specific molecule is involved, or to find structures for associate protein components, for example. BioSystems can be searched with very simple keyword or ID queries, or you can utilize some of the many types of advanced searches offered. Because BioSystems is part of NCBI’s Entrez system of databases you have access to a tremendous variety of tools to customize your searches and results, and to find more information. The links to related data are extensive, and allow you to further your explorations by linking to the biological system’s associated literature, molecular and chemical data.|
- to perform basic searches and to understand your results
- to link out to a variety of related information in many different fields
- about some Entrez tools that you can use to customize your searches and results
- how to access and customize full-size pathway images
- some advanced searching techniques, including Boolean queries and batch searching
Recent BioMed Central research articles citing this resource
Stevens Adam et al., Can network biology unravel the aetiology of congenital hyperinsulinism?. Orphanet Journal of Rare Diseases (2013) doi:10.1186/1750-1172-8-21
Gruszka Damian et al., The barley EST DNA Replication and Repair Database (bEST-DRRD) as a tool for the identification of the genes involved in DNA replication and repair. BMC Plant Biology (2012) doi:10.1186/1471-2229-12-88
Cui Guangyu et al., Prediction of protein-protein interactions between viruses and human by an SVM model Advanced intelligent computing theories and their applications in bioinformatics. Proceedings of the 2011 International Conference on Intelligent Computing (ICIC 2011) The 2011 International Conference on Intelligent Computing (ICIC 2011). BMC Bioinformatics (2012) doi:10.1186/1471-2105-13-S7-S5
Iourov Y Ivan et al., Molecular karyotyping by array CGH in a Russian cohort of children with intellectual disability, autism, epilepsy and congenital anomalies. Molecular Cytogenetics (2012) doi:10.1186/1755-8166-5-46
Xu Yu et al., Gene therapy with tumor-specific promoter mediated suicide gene plus IL-12 gene enhanced tumor inhibition and prolonged host survival in a murine model of Lewis lung carcinoma. Journal of Translational Medicine (2011) doi:10.1186/1479-5876-9-39
More about the resource:
BioSystems is brought to you by The National Center for Biotechnology Information (NCBI) which is part of the National Library of Medicine (NLM) at the National Institutes of Health (NIH). Currently BioSystems imports data from KEGG, and the EcoCyc subset of BioCyc. BioSystems will expand to include more data sources in the future, as more data becomes available.
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